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Ménière's disease is a viral neuropathy.

TitleMénière's disease is a viral neuropathy.
Publication TypeJournal Article
Year of Publication2009
AuthorsGacek RR
JournalORL J Otorhinolaryngol Relat Spec
Volume71
Issue2
Pagination78-86
Date Published2009
ISSN1423-0275
KeywordsAged, Aged, 80 and over, Endolymphatic Hydrops, Female, Humans, Male, Meniere Disease, Microscopy, Electron, Transmission, Middle Aged, Severity of Illness Index, Spiral Ganglion, Vestibular Neuronitis, Vestibule, Labyrinth
Abstract

<p>Morphological and clinical evidence supports a viral neuropathy in Ménière's disease (MD). Quantitative examination of 11 sectioned temporal bones (TBs) from 8 patients with a history of MD revealed a significant loss of vestibular ganglion cells in both the endolymph hydropic (EH) and non-EH ears. Transmission electron microscopy of vestibular ganglion cells excised from a patient with MD revealed viral particles enclosed in transport vesicles. Antiviral treatment controlled vertigo in 73 of 86 patients with vestibular neuronitis (85%) and 32 of 35 patients with MD (91%).</p>

DOI10.1159/000189783
Alternate JournalORL J. Otorhinolaryngol. Relat. Spec.
Citation KeyCK29
PubMed ID19142031