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Meniett therapy: rescue treatment in severe drug-resistant Ménière's disease?

TitleMeniett therapy: rescue treatment in severe drug-resistant Ménière's disease?
Publication TypeJournal Article
Year of Publication2005
AuthorsBoudewyns AN, Wuyts FL, Hoppenbrouwers M, Ketelslagers K, Vanspauwen R, Forton G, Van de Heyning PH
JournalActa Otolaryngol
Volume125
Issue12
Pagination1283-9
Date Published2005 Dec
ISSN0001-6489
KeywordsAdult, Drug Resistance, Microbial, Female, Follow-Up Studies, Gentamicins, Humans, Injections, Intralesional, Male, Meniere Disease, Middle Aged, Middle Ear Ventilation, Probability, Prospective Studies, Risk Assessment, Severity of Illness Index, Statistics, Nonparametric, Treatment Outcome, Tympanic Membrane
Abstract

<p><b>CONCLUSION: </b>Our data indicate that Meniett therapy is unlikely to be helpful in the long-term treatment of patients with severe, drug-resistant Ménière's disease (MD) in whom injection of intratympanic gentamicin (ITG) or another destructive procedure would otherwise be performed.</p><p><b>OBJECTIVE: </b>To investigate the value of Meniett therapy in patients with drug-resistant MD referred for injection of ITG.</p><p><b>MATERIAL AND METHODS: </b>Twelve patients referred for ITG treatment were followed during a 2-month period of Meniett therapy. Symptoms, functional level and hearing status were evaluated using a standardized staging system. Disease-specific quality-of-life measures were obtained before and after Meniett therapy. At the end of the study period, patients were followed for a mean of 37 months, thus providing long-term outcome data.</p><p><b>RESULTS: </b>In two patients, Meniett treatment was interrupted after 1 month because of persistent severe vertigo. In the remaining 10 subjects, we found a significant decrease in the median number of vertigo spells from 10.0/month (25th-75th percentile 4.0-19.0) prior to treatment to 3.0/month (25th-75th percentile 1.5-4.5) after treatment (p = 0.02). There was, however, no improvement in hearing status, tinnitus, functional level or self-perceived dizziness handicap. Long-term (>1 year) follow-up data revealed that only 2 subjects preferred to continue Meniett therapy and that ablative surgery had to be performed in 6/12 study patients.</p>

DOI10.1080/00016480510012237
Alternate JournalActa Otolaryngol.
Citation KeyCK35
PubMed ID16303675