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Intratympanic gentamicin injections for Meniere disease: vestibular hair cell impairment and regeneration.

TitleIntratympanic gentamicin injections for Meniere disease: vestibular hair cell impairment and regeneration.
Publication TypeJournal Article
Year of Publication2002
AuthorsDe Waele C, Meguenni R, Freyss G, Zamith F, Bellalimat N, Vidal PP, P Huy TBa
JournalNeurology
Volume59
Issue9
Pagination1442-4
Date Published2002 Nov 12
ISSN0028-3878
KeywordsAdult, Aged, Anti-Bacterial Agents, Caloric Tests, Evoked Potentials, Auditory, Female, Gentamicins, Hair Cells, Vestibular, Humans, Male, Meniere Disease, Middle Aged, Nerve Regeneration, Saccades, Treatment Outcome, Tympanic Membrane
Abstract

<p>The authors treated 22 patients with intratympanic gentamicin. Vestibular function was measured using caloric and head impulse tests and vestibular evoked myogenic potentials induced by high amplitude sounds and short duration galvanic currents. Roughly one-third of the patients, after initially losing their caloric responses and displaying refixation saccades to head impulse tests, recovered within 2 years of the lesion. Vertigo did not recur in patients in whom the galvanic response was abolished.</p>

Alternate JournalNeurology
Citation KeyCK43
PubMed ID12427902