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Vestibular function and vertigo control after intratympanic gentamicin for Ménière's disease.

TitleVestibular function and vertigo control after intratympanic gentamicin for Ménière's disease.
Publication TypeJournal Article
Year of Publication2009
AuthorsNguyen KD, Minor LB, Santina CCDella, Carey JP
JournalAudiol Neurootol
Volume14
Issue6
Pagination361-72
Date Published2009
ISSN1421-9700
KeywordsAnti-Bacterial Agents, Caloric Tests, Chi-Square Distribution, Databases, Factual, Drug Administration Routes, Eye Movements, Gentamicins, Head Movements, Humans, Meniere Disease, Recovery of Function, Recurrence, Reflex, Vestibulo-Ocular, Regression Analysis, Semicircular Canals, Statistics, Nonparametric, Treatment Outcome, Vertigo
Abstract

<p>The aim of this study was to correlate long-term vertigo control with reduction in vestibular function after intratympanic (IT) gentamicin therapy for unilateral Ménière's disease. IT gentamicin injections were given as needed to control vertigo attacks. Vertigo frequency and changes in angular vestibulo-ocular reflex (AVOR) gain (measured using magnetic search coils and manual head thrusts) and caloric weakness were assessed before and after treatment. Better vertigo control after treatment was found with >or=60% reduction in quantitative ipsilateral horizontal semicircular canal AVOR gain from pre-treatment values and/or with caloric unilateral weakness (UW) >50%. However, no correlations were found between the continuous variables of vertigo control and either gain or gain recovery, nor between gain and UW because of the large variability in vertigo control in subjects with lesser reductions in these measures.</p>

DOI10.1159/000241893
Alternate JournalAudiol. Neurootol.
Citation KeyCK44
PubMed ID19923806
PubMed Central IDPMC2820329
Grant ListR01 DC05040 / DC / NIDCD NIH HHS / United States