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Vestibular neuritis: clinical-pathologic correlation.

TitleVestibular neuritis: clinical-pathologic correlation.
Publication TypeJournal Article
Year of Publication1996
AuthorsBaloh RW, Ishyama A, Wackym PA, Honrubia V
JournalOtolaryngol Head Neck Surg
Date Published1996 Apr
KeywordsAged, Caloric Tests, Ear, Inner, Hair Cells, Auditory, Humans, Immunohistochemistry, Male, Neuritis, Synapses, Vestibular Nerve, Vestibular Nuclei, Virus Diseases

<p>Postmortem examination of the brain and temporal bones of a patient with well-documented vestibular neuritis showed selective neuronal loss in Scarpa's ganglia on the side with absent caloric response. There was loss of hair cells and an "epithelialization" of the utricular macule and semicircular canal cristae on the deafferented side, and synaptic density in the vestibular nuclei on the deafferented side was decreased compared with that on the normal side. All findings were consistent with an isolated viral infection of Scarpa's ganglia. This is the first description of the effects of chronic deafferentation on the vestibular sensory epithelia and the vestibular nuclei in a human being.</p>

Alternate JournalOtolaryngol Head Neck Surg
Citation KeyCK73
PubMed ID8643269
Grant ListAG09693 / AG / NIA NIH HHS / United States
DC01404 / DC / NIDCD NIH HHS / United States