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Latency of herpes simplex virus type-1 in human geniculate and vestibular ganglia is associated with infiltration of CD8+ T cells.

TitleLatency of herpes simplex virus type-1 in human geniculate and vestibular ganglia is associated with infiltration of CD8+ T cells.
Publication TypeJournal Article
Year of Publication2010
AuthorsArbusow V, Derfuss T, Held K, Himmelein S, Strupp M, Gurkov R, Brandt T, Theil D
JournalJ Med Virol
Volume82
Issue11
Pagination1917-20
Date Published2010 Nov
ISSN1096-9071
KeywordsAdult, CD8-Positive T-Lymphocytes, Child, Child, Preschool, Geniculate Ganglion, Herpesvirus 1, Human, Humans, Immunohistochemistry, In Situ Hybridization, Infant, MicroRNAs, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction, Vestibular Nerve, Virus Latency
Abstract

<p>Herpes simplex virus type-1 latency and CD8+ T-cell occurrence were investigated in the trigeminal, geniculate, and vestibular ganglia from seven deceased humans. The HSV-1 "latency-associated transcript" was assessed by in situ hybridization and quantitative RT-PCR. Infiltration of CD8+ T cell was detected by immunohistochemistry and quantitative RT-PCR. The data show that HSV-1 latency and CD8+ T-cell infiltration are not solely confined to the trigeminal ganglia but can also occur in other cranial ganglia along the neuroaxis. However, the HSV-1 latency transcripts in the geniculate and vestibular ganglia were expressed at a very low level. The difference in CD8 transcript levels among HSV-1 latently infected trigeminal ganglia, geniculate, and vestibular ganglia was less conspicuous. Colocalization of latent HSV-1 and CD8+ T cells in geniculate and vestibular ganglia supports further the hypothesis that HSV-1 reactivation is possible in these ganglia and is the cause of Bell's palsy and vestibular neuritis.</p>

DOI10.1002/jmv.21904
Alternate JournalJ. Med. Virol.
Citation KeyCK74
PubMed ID20872719