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Menière's disease as a manifestation of vestibular ganglionitis.

TitleMenière's disease as a manifestation of vestibular ganglionitis.
Publication TypeJournal Article
Year of Publication2001
AuthorsGacek RR, Gacek MR
JournalAm J Otolaryngol
Volume22
Issue4
Pagination241-50
Date Published2001 Jul-Aug
ISSN0196-0709
KeywordsAged, Aged, 80 and over, Female, Fibrosis, Humans, Labyrinthitis, Male, Meniere Disease, Middle Aged, Temporal Bone, Vestibulocochlear Nerve Diseases
Abstract

<p><b>OBJECTIVE: </b>To present morphologic evidence of viral-induced vestibular nerve pathology in Menière's Disease (MD). MATERIAL STUDIED: Twelve temporal bones (TB) from 8 patients with the clinical symptoms of MD.</p><p><b>RESULTS: </b>There was endolymphatic hydrops (EH) and perilymphatic fibrosis in 10 of the 12 TB from MD patients. Of the 10 TB with EH of the pars inferior, 3 also contained outpouchings in the pars superior (utricle and canals), and 3 showed apical spiral ganglion cell loss. Focal vestibular nerve axonal degeneration was observed in all but one TB.</p><p><b>CONCLUSION: </b>Morphologic changes in TB of patients with MD, and clinical observations in patients with recurrent vestibulopathy, support the concept that the pathologic mechanism responsible for auditory and vestibular symptoms in MD may be reactivation of a latent viral vestibular ganglionitis.</p>

DOI10.1053/ajot.2001.24822
Alternate JournalAm J Otolaryngol
Citation KeyCK86
PubMed ID11464320